Severin



Severin is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative severin structure, i.e. the human severin (3fg6). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. It is named Adseverin and Scinderin as well. The image at the right is the severin with calcium ions (colored lime ).

3D Structures of Severin
3fg6 – Adseverin C-terminal – human

1svy – DdSeverin domain 2 – Dictyostelium discoideum

1svq, 1svr - DdSeverin domain 2 - Dictyostelium discoideum, NMR